I started out with the defaults and had (and still have) excellent results. What I initially did was to set the discrimination to 55, notch the full nickels range back in. Use "dE" (default) for the mode and 2F for the tones. The sensitivity may need to be toned down a bit. For a VERY stable setting keep it in the 30 to 34 range. I FASTGRAB ground balance (push the trigger toggle forward and pump the coil up and down 6" about three times - it either takes or tells you "Can't GB" in which case you move two feet and try again) and then hold the coil just off the ground and set the sensitivity up until it starts to false, then lower it three or four units.
As you get used to the audio you may want to switch to 3H or 4H. These give a higher tone for nickels (and some other nickel-like conductivity targets). The F-75 loves nickels and is hot on dimes, also.
Stay out of Jewelry mode for the first 16 or so hours of use. It is wild but may eventually be useful to you (I'm just starting to use it). "bc" mode (bottle cap) gives those objects a wider TID swing as you sweep them but also gives you the impression the meter is hopping all over. Don't use it unless you're willing to have that. Individual coins stay within one or two units, but similar coins in other angles and depths (and condition) may read slightly higher or lower; but still hold a narrow range once detected. Cents, for instance, can be a 60 or a 70 depending on year (the alloy was changed in '82).